Over-expression of severe acute respiratory syndrome coronavirus 3b protein induces both apoptosis and necrosis in Vero E6 cells
Identifieur interne : 003D94 ( Main/Exploration ); précédent : 003D93; suivant : 003D95Over-expression of severe acute respiratory syndrome coronavirus 3b protein induces both apoptosis and necrosis in Vero E6 cells
Auteurs : Sehaam Khan ; Burtram C. Fielding ; Timothy H. P. Tan ; Chih-Fong Chou ; Shuo Shen ; Seng Gee Lim ; Wanjin Hong ; Yee-Joo TanSource :
- Virus Research [ 0168-1702 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Apoptose, Cellules Vero, Délétion de séquence, Facteurs temps, Fragmentation de l'ADN, Microscopie de fluorescence, Noyau de la cellule (), Nucléole (), Nécrose, Protéine Bax (physiologie), Protéines virales non structurales (génétique), Protéines virales non structurales (métabolisme), Protéines virales non structurales (physiologie), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Protéines virales non structurales.
- métabolisme : Protéines virales non structurales.
- pathogénicité : Virus du SRAS.
- physiologie : Protéine Bax, Protéines virales non structurales.
- Animaux, Apoptose, Cellules Vero, Délétion de séquence, Facteurs temps, Fragmentation de l'ADN, Microscopie de fluorescence, Noyau de la cellule, Nucléole, Nécrose.
English descriptors
- KwdEn :
- Animals, Apoptosis, Cell Nucleolus (chemistry), Cell Nucleus (chemistry), Chlorocebus aethiops, DNA Fragmentation, Microscopy, Fluorescence, Necrosis, SARS Virus (pathogenicity), Sequence Deletion, Time Factors, Vero Cells, Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism), Viral Nonstructural Proteins (physiology), bcl-2-Associated X Protein (physiology).
- MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- chemistry : Cell Nucleolus, Cell Nucleus.
- chemical , metabolism : Viral Nonstructural Proteins.
- pathogenicity : SARS Virus.
- chemical , physiology : Viral Nonstructural Proteins, bcl-2-Associated X Protein.
- Animals, Apoptosis, Chlorocebus aethiops, DNA Fragmentation, Microscopy, Fluorescence, Necrosis, Sequence Deletion, Time Factors, Vero Cells.
Abstract
The genome of the severe acute respiratory syndrome coronavirus encodes for eight accessory viral proteins with no known homologues in other coronaviruses. One of these is the 3b protein, which is encoded by the second open reading frame in subgenomic RNA 3 and contains 154 amino acids. Here, a detailed time-course study was performed to compare the apoptosis and necrosis profiles induced by full-length 3b, a 3b mutant that was deleted by 30 amino acids from the C terminus (3bΔ124-154) and the classical apoptosis inducer, Bax. Our results showed that Vero E6 cells transfected with a construct for expressing 3b underwent necrosis as early as 6 h after transfection and underwent simultaneous necrosis and apoptosis at later time-points. At all the time-points analysed, the apoptosis induced by the expression of 3b was less than the level induced by Bax but the level of necrosis was comparable. The 3bΔ124-154 mutant behaves in a similar manner indicating that the localization of the 3b protein does not seems to be important for the cell-death pathways since full-length 3b is localized predominantly to the nucleolus, while the mutant is found to be concentrated in the peri-nuclear regions. To our knowledge, this is the first report of the induction of necrosis by a SARS-CoV protein.
Url:
DOI: 10.1016/j.virusres.2006.06.005
PubMed: 16965829
PubMed Central: 7114230
Affiliations:
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Fielding</name></author><author><name sortKey="Tan, Timothy H P" sort="Tan, Timothy H P" uniqKey="Tan T" first="Timothy H. P." last="Tan">Timothy H. P. Tan</name></author><author><name sortKey="Chou, Chih Fong" sort="Chou, Chih Fong" uniqKey="Chou C" first="Chih-Fong" last="Chou">Chih-Fong Chou</name></author><author><name sortKey="Shen, Shuo" sort="Shen, Shuo" uniqKey="Shen S" first="Shuo" last="Shen">Shuo Shen</name></author><author><name sortKey="Lim, Seng Gee" sort="Lim, Seng Gee" uniqKey="Lim S" first="Seng Gee" last="Lim">Seng Gee Lim</name></author><author><name sortKey="Hong, Wanjin" sort="Hong, Wanjin" uniqKey="Hong W" first="Wanjin" last="Hong">Wanjin Hong</name></author><author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Cell Nucleolus (chemistry)</term><term>Cell Nucleus (chemistry)</term><term>Chlorocebus aethiops</term><term>DNA Fragmentation</term><term>Microscopy, Fluorescence</term><term>Necrosis</term><term>SARS Virus (pathogenicity)</term><term>Sequence Deletion</term><term>Time Factors</term><term>Vero Cells</term><term>Viral Nonstructural Proteins (genetics)</term><term>Viral Nonstructural Proteins (metabolism)</term><term>Viral Nonstructural Proteins (physiology)</term><term>bcl-2-Associated X Protein (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Cellules Vero</term><term>Délétion de séquence</term><term>Facteurs temps</term><term>Fragmentation de l'ADN</term><term>Microscopie de fluorescence</term><term>Noyau de la cellule ()</term><term>Nucléole ()</term><term>Nécrose</term><term>Protéine Bax (physiologie)</term><term>Protéines virales non structurales (génétique)</term><term>Protéines virales non structurales (métabolisme)</term><term>Protéines virales non structurales (physiologie)</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Cell Nucleolus</term><term>Cell Nucleus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales non structurales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines virales non structurales</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéine Bax</term><term>Protéines virales non structurales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Viral Nonstructural Proteins</term><term>bcl-2-Associated X Protein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Chlorocebus aethiops</term><term>DNA Fragmentation</term><term>Microscopy, Fluorescence</term><term>Necrosis</term><term>Sequence Deletion</term><term>Time Factors</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Cellules Vero</term><term>Délétion de séquence</term><term>Facteurs temps</term><term>Fragmentation de l'ADN</term><term>Microscopie de fluorescence</term><term>Noyau de la cellule</term><term>Nucléole</term><term>Nécrose</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The genome of the severe acute respiratory syndrome coronavirus encodes for eight accessory viral proteins with no known homologues in other coronaviruses. One of these is the 3b protein, which is encoded by the second open reading frame in subgenomic RNA 3 and contains 154 amino acids. Here, a detailed time-course study was performed to compare the apoptosis and necrosis profiles induced by full-length 3b, a 3b mutant that was deleted by 30 amino acids from the C terminus (3bΔ124-154) and the classical apoptosis inducer, Bax. Our results showed that Vero E6 cells transfected with a construct for expressing 3b underwent necrosis as early as 6 h after transfection and underwent simultaneous necrosis and apoptosis at later time-points. At all the time-points analysed, the apoptosis induced by the expression of 3b was less than the level induced by Bax but the level of necrosis was comparable. The 3bΔ124-154 mutant behaves in a similar manner indicating that the localization of the 3b protein does not seems to be important for the cell-death pathways since full-length 3b is localized predominantly to the nucleolus, while the mutant is found to be concentrated in the peri-nuclear regions. To our knowledge, this is the first report of the induction of necrosis by a SARS-CoV protein.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ameison, J C" uniqKey="Ameison J">J.C. Ameison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="An, K" uniqKey="An K">K. An</name></author><author><name sortKey="Fattaey, H K" uniqKey="Fattaey H">H.K. Fattaey</name></author><author><name sortKey="Paulsen, A Q" uniqKey="Paulsen A">A.Q. Paulsen</name></author><author><name sortKey="Consigli, R A" uniqKey="Consigli R">R.A. 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Fielding</name><name sortKey="Hong, Wanjin" sort="Hong, Wanjin" uniqKey="Hong W" first="Wanjin" last="Hong">Wanjin Hong</name><name sortKey="Khan, Sehaam" sort="Khan, Sehaam" uniqKey="Khan S" first="Sehaam" last="Khan">Sehaam Khan</name><name sortKey="Lim, Seng Gee" sort="Lim, Seng Gee" uniqKey="Lim S" first="Seng Gee" last="Lim">Seng Gee Lim</name><name sortKey="Shen, Shuo" sort="Shen, Shuo" uniqKey="Shen S" first="Shuo" last="Shen">Shuo Shen</name><name sortKey="Tan, Timothy H P" sort="Tan, Timothy H P" uniqKey="Tan T" first="Timothy H. P." last="Tan">Timothy H. P. Tan</name><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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